None Hodgkin’s Lymphoma, an Overview and Update on the Treatment

The last decade observed a plethora of scientific research on the best agents for treating Diffuse Large B-cell non-Hodgkin’s Lymphoma (DLBC) beyond the standard chemotherapy protocols (CHOPR) for CD20+ DLBC NHL. Recently, Mondello P and Nowakowski published research on The Treatment of Aggressive B Cell Lymphomas: Published on May 2020 in the Journal of Current  Hematological  Malignancy reports https://www.ncbi.nlm.nih.gov/pubmed/32372238  

According to the authors, over the last few years, many gene expression profiles were researched for the  Diffuse Large B Cell None Hodgkin’s Lymphoma trying to add more gene-targeting therapies with the aim of gradual replacement of the chemotherapy (CHOP) either partially or totally with gene-based therapies ( sometimes it is called precision therapies). Such clinical trials aimed to introduce less toxic systemic therapies (Gene Targeting treatments) replacing the more toxic systemic chemotherapies with many short- and long-term toxicities and dose constraints. This research represented an overview and update on the treatment of non-Hodgkin's Lymphoma. 

One of the most popular recent immune therapies tried for DLBC Non-Hodgkin’s Lymphoma was the Immunotherapy CAR T cell ( Chimeric Antigen Receptor T cell) Immune therapy which is based on the infusion of a genetically modified T Lymphocytes expressing the Chimeric Antigen Receptor which will reprogram the T cells of the body to be more functional and enhance body immune response against lymphoma.

The conclusion from this study was that, despite the huge number of clinical trials testing the different target and immunological therapies in the treatment of Diffuse Large B cell Lymphoma, None of these interventions showed a better or even equal response and survival results as the standard chemotherapy CHOPR.

 

 

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