The last decade observed a plethora of scientific research on the best agents for treating Diffuse Large B-Cell None Hodgkin’s Lymphoma (DLBC) beyond the standard chemotherapy protocols (CHOPR) for CD20+ DLBC NHL. Recently, Mondello P and Nowakowski published research on The Treatment of Aggressive B Cell Lymphomas: Published on May 2020 in the Journal of Current Hematological Malignancy reports https://www.ncbi.nlm.nih.gov/pubmed/32372238
According to the authors, over the last few years, many gene expression profiles were researched for the Diffuse Large B Cell None Hodgkin’s Lymphoma trying to add more gene-targeting therapies with the aim of gradual replacement of the chemotherapy (CHOP) either partially or totally with gene-based therapies ( sometimes it is called precision therapies). The aim for such clinical trials was to introduce less toxic systemic therapies (Gene Targeting treatments) replacing the more toxic systemic chemotherapies with many short- and long-term toxicities and dose constraints. This research represented an overview and update on the treatment of Non-Hodgkin's Lymphoma.
One of the most popular recent immune therapies tried for the DLBC None Hodgkin’s Lymphoma was the Immunotherapy CAR T cell ( Chimeric Antigen Receptor T cell) Immune therapy which is based on the infusion of a genetically modified T Lymphocytes expressing the Chimeric Antigen Receptor which will reprogram the T cells of the body to be more functional and enhance body immune response against lymphoma.
The conclusion from this study was that, in spite of the huge number of the clinical trials testing the different target and immunological therapies in the treatment of Diffuse Large B cell Lymphoma, None of these interventions showed a better or even equal response and survival results as the standard chemotherapy CHOPR.
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