Intravenous High Dose Magnesium and Hydration Protects Against Cisplatin Chemotherapy Toxicity for Lung Cancer
One of the consequences of chemotherapy Cisplatin for treating Lung Cancer is the development of Kidney toxicity. The development of kidney toxicity with this Chemotherapy is inevitable as Chemotherapy does not target the Lung Cancer Cells only, it goes all over the body including the kidneys. The conflict here is that, this Chemotherapy (Cisplatin) is one of the most active Chemotherapies for lung cancer and is usually used with many other combinations such as Taxol or Gemcitabine. However, medical oncologists usually add a hydration intravenous infusion before and after Cisplatin Chemotherapy infusion to avoid the impact of the Cisplatin Chemotherapy on the kidney cells and to reduce kidney damage as much as they can.
In this article, a Research was done by oncologists at Osaka in Japan, about the Intravenous High Dose Magnesium and Hydration Protects Against Cisplatin Chemotherapy Toxicity for Lung Cancer. In this Research, the Oncologists assume that giving chemotherapy Cisplatin can result in kidney damage due to many factors one of which is depletion of the body magnesium, so they propose adding high dose magnesium to the hydration infusion can be beneficial in protection against the kidney damage after Cisplatin Chemotherapy Infusion.
In this Research, 85 patients with Lung Cancer were treated at Osaka University Oncology Centre with Cisplatin Chemotherapy, were divided into 3 groups, one group with a standard Pre chemotherapy and Post chemotherapy Intravenous Hydration Only with No magnesium, a second group with the same hydration as the first group but with high dose Magnesium and a third group with Low Dose Magnesium.
Results: The only group that showed a preserved kidney function with no Kidney Function Impairment was the group who received a High dose magnesium with the Intravenous Hydration as compared to the other 2 groups.
Conclusion: The addition of high dose magnesium to the Intravenous Fluid Infusion in the Pre and Post Hydration Can be very effective in protecting the Kidneys from the damage caused by Cisplatin Chemotherapy in Lung Cancer Patients.
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